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Systemic Lupus Erythematosus

Lahita, Robert G.; Koike, Takao; Buyon, Jill P.; Tsokos, George C.
ISBN-10: 0123749948
ISBN-13: 9780123749949

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Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood.
Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.Lupus is the prototypic autoimmune disease and Systemic Lupus Erythematosus examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. * Highly illustrated and in full color throughout * Basic science section expanded, allowing the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment * Clinical aspects and new drugs are covered in great detail providing a useful reference to professionals interested in lupus
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Basis of Disease Pathogenesis
Genetics
Major histocompatibility complex class II
Genetic susceptibility and class III complement genes
Constitutive genes and lupus
Genetics of lupus in mice
Tolerance and autoimmunity
Dendritic cells in SLE
T cells and systemic lupus erthematosus
B-lymphocyte biology in SLE
Polymorhonuclear and endothelial cells
Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE
Cell cycle regulation and systemic lupus erythematosus
The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus
Origins of antinuclear antibodies
Anti-DNA antibodies: Structure, regulation and pathogenicity
Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis
Antihistone and antispliceosomal antibodies
Toll-like receptors in SLE
Interferon-alpha in systemic lupus erythematosus
Immune complexes in systemic lupus erythematosus
Complement and tissue injury in SLE
Humoral pathogenesis: Fc receptors in autoimmunity and end-organ damage
Environmental Aspects of Pathogenesis
Drug-induced lupus mechanisms
Gender and age in lupus
Roles for infections in systemic lupus erythematosus pathogenesis
Systemic lupus erythematosus in domestic animals
Mechanisms of Tissue Injury
Pathogenesis of lupus nephritis
Tissue injury and the skin
Neuropsychiatric systemic lupus erythematosus: Mechanisms of injury
Atherosclerosis and tissue injury in systemic lupus erythematosus
Clinical Aspects of Disease
Clinical Presentation
The clinical presentation of systemic lupus erythematosus
Neonatal lupus
SLE in children
Drug-induced disease
Laboratory evaluation of patients with systemic lupus erythematosus
Pregnancy and reproductive concerns in systemic lupus erythematosus
Epidemiology of systemic lupus erythematosus
Monitoring disease activity
Incomplete lupus erythematosus
Design of clinical trials for SLE
Organ Systems
The nervous system and lupus
Skin
Kidney
Heart
Vasculitis
Lung
Gastrointestinal: Liver
Gastrointestinal: Nonhepatic
Cellular hematology
Musculoskeletal system: Articular disease, bone metabolism
Anti-Phospholipid Syndrome
Pathogenesis
Antiphospholipid antibody: Pathogenesis
Endothelial cell damage and atherosclerosis
Clinical
Laboratory testing for antiphospholipid syndrome
Clinical presentation of antiphospholipid syndrome
Pregnancy and antiphospholipid syndrome
Treatment of antiphospholipid syndrome
Treatment
Steroids and nonsteroidal anti-inflammatory drugs
Antimalarials
Cytotoxic agents
Biological agents





Edition: 5th 2010
Publisher: Elsevier Science & Technology
Binding: Trade Cloth
Pages: 1154
Size: 8.50" wide x 10.87" long x 2.25" tall
Weight: 7.90 lbs.
Language: English

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