Glioblastoma multiforme (GBM) is the most aggressive form of primary brain tumor. Numerous studies have tried to explore various avenues to make this tumor sensitive to radiation therapy and improve the prognosis for patients with this tumor. However, the prognosis for patients with this tumor remains poor with median survival time less than one year.
By using current concepts and techniques of local drug delivery to the brain to sensitize the tumor to radiation therapy, we were able to greatly improve the median survival time in an animal model.
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